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OE Companion Discussion Group

CLAMP was observed to encourages roX2 transcription in males but represses transcription of equally roX genes in girls. MSL2, which binds roX1 RNA and is an critical member of the dosage compensation elaborate, is not necessary for total expression of heterochromatic genes in males. It is possible that recruitment of the MSL complex to the roX2 locus by CLAMP encourages roX2 expression in males. Additionally, it was decided that most clamp2 homozygous males die previously in growth than clamp2 homozygous girls. An intriguing observation that arose from this characterization is that polytene chromosome business is disrupted in clamp2 mutant girls, suggesting that CLAMP may perhaps participate in a part in regulation of genome-huge chromatin firm of interphase chromosomes. A research for the genetic regulators of the sex difference in autosomal heterochromatin removed the Y chromosome and the standard sexual intercourse resolve pathway, suggesting that the variety of X chromosomes decides the sensitivity of autosomal heterochromatin to decline of roX action.